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Neurobiological mechanisms underlying abnormal processing of guilt, disgust and intentionality in obsessive-compulsive disorder: A critical review

Barbara Basile, Francesco Mancini

ABSTRACT: Many different and innovative neuroimaging techniques have been developed in the last decades. Functional neuroimaging allows detecting what is happening in our brain at rest or while performing a specific cognitive or emotional task, while structural methods are concerned with the physical organization of the brain, considering both micro- and macro-structural aspects. Starting from these recent developments, ...

Journal Article: Clinical Neuropsychiatry, 11 (6), pp. 187-193, 2014.



Abnormal processing of deontological guilt in obsessive--compulsive disorder

Barbara Basile and Francesco Mancini and Emiliano Macaluso and Carlo Caltagirone and Marco Bozzali

ABSTRACT: Guilt plays a significant role in the occurrence and maintenance of obsessive--compulsive disorder (OCD). Two major types of guilt have been identified: one deriving from the transgression of a moral rule (deontological guilt DG), another (altruistic guilt AG), relying on the assumption of having compromised a personal altruistic goal. Clinical evidence suggests that OCD patients are particularly sensitive to DG, ...

Journal Article: Brain Structure and Function, 219 (4), pp. 1321–1331, 2013, ISSN: 1863-2661.